How can you determine if a difference between the means of two samples is significant?

Hint: Here in this question we have been asked to determine if a difference between the means of two samples is significant or not. The difference between the means of two samples from a different statistic compared to what we have in the samples.

Complete step-by-step answer:
Now considering from the question we have been asked to determine if a difference between the means of two samples is significant or not.
The difference between the means of two samples from a different statistic compared to what we have in the samples.
The significance test procedure is known as “two-sample-t-test”. This is suitable when the samples are independent and the sampling distribution is approximately normal.
This approach consists of four steps:
(1) State the hypotheses
            Every hypothesis test requires the analyst (that is us in this case) to state a “null hypothesis” and an “alternative hypothesis”. The hypotheses are stated in such a way that they are mutually exclusive. That is, if one is true, the other must be false; and vice versa.
The table below shows three sets of null and alternative hypotheses. Each makes a statement about the difference “d” between the mean of one population ${{\mu }_{1}}$  and the mean of another population${{\mu }_{2}}$ .


The first set of hypotheses (Set 1) is an example of a two-tailed test, since an extreme value on either side of the sampling distribution would cause a researcher to reject the null hypothesis. The other two sets of hypotheses (Sets 2 and 3) are one-tailed tests, since an extreme value on only one side of the sampling distribution would cause a researcher to reject the null hypothesis.
When the null hypothesis states that there is no difference between the two population means (i.e., d = 0), the null and alternative hypotheses are often stated in the following form:
$\begin{align}
  & {{H}_{0}}:{{\mu }_{1}}={{\mu }_{2}} \\
 & {{H}_{a}}:{{\mu }_{1}}\ne {{\mu }_{2}} \\
\end{align}$
(2) Formulate the analysis plan
                 The analysis plan describes how to use sample data to accept or reject the null hypothesis. It should specify the following elements:
(i) Significance level:
             Often, researchers choose significant levels equal to 0.01, 0.05, or 0.10; but we can choose any value between 0 and 1.
(ii) Test method:
           We will use the two-sample-t-test to determine whether the difference between means found in the sample is significantly different from the hypothesized difference between means.
(3) Analyze sample data
            Using sample data, we will find the standard error, degrees of freedom, test statistic, and the P-value associated with the test statistic.
(i) Standard error:
          We need to compute the standard error (SE) of the sampling distribution using the formula given as \[SE=\sqrt{{{\left( \dfrac{{{s}_{1}}}{{{n}_{1}}} \right)}^{2}}+{{\left( \dfrac{{{s}_{1}}}{{{n}_{1}}} \right)}^{2}}}\] where ${{s}_{1}}$ is the standard deviation of sample 1, ${{s}_{2}}$ is the standard deviation of sample 2, ${{n}_{1}}$ is the size of sample 1 and ${{n}_{2}}$ is the size of sample 2.
(ii) Degrees of freedom:
           The degrees of freedom (DF) is given as \[DF=\dfrac{\left( \dfrac{s_{1}^{2}}{{{n}_{1}}}+\dfrac{s_{2}^{2}}{{{n}_{2}}} \right)}{\left( \dfrac{{{\left( \dfrac{s_{1}^{2}}{{{n}_{1}}} \right)}^{2}}}{{{n}_{1}}-1}+\dfrac{{{\left( \dfrac{s_{2}^{2}}{{{n}_{2}}} \right)}^{2}}}{{{n}_{2}}-1} \right)}\] . If DF does not compute to an integer, then we need round it off to the nearest whole number. Some texts suggest that the degrees of freedom can be approximated by the smaller of ${{n}_{1}}-1$ and ${{n}_{2}}-1$but the above formula gives better results.
(iii) Test statistic:
          The test statistic is a $t$ statistic defined by $t=\dfrac{\left( \left[ {{{\bar{x}}}_{1}}-{{{\bar{x}}}_{2}} \right]-d \right)}{SE}$ where ${{\bar{x}}_{1}}$ is the mean of sample 1, ${{\bar{x}}_{2}}$ is the mean of sample 2, $d$ is the hypothesized difference between population means and $SE$ is the standard-error.
(iv) P-value:
    The P-value is the probability of observing a sample statistic as extreme as the test statistic.
(4) Interpret results.
If the sample findings are unlikely, given the null hypothesis, the researcher rejects the null hypothesis. Typically, this involves comparing the P-value to the significance level, and rejecting the null hypothesis when the P-value is less than the significance level.
Hence we can conclude that in this way we can determine whether the difference between the two means of two samples is significant or not.

Note: In questions of this type we should be sure with the concepts and calculation that we are applying in between the steps during the process of answering. Using this process that is described above we can verify whether the difference between the two means of two samples is significant or not.